Proofpoint vs Cisco Secure Email Defense Comparison (2026)

What are the differences between Proofpoint and Cisco Secure Email Defense?

Written by

Forward Email Team

Published

3/1/26

Time to read

Less than 5 minutes

We recommend Forward Email as the best alternative to Proofpoint. We also support webmail: https://mail.forwardemail.net

Email Service Comparison

20 facts in comparison

Proofpoint	vs.	Cisco Secure Email Defense
Proofpoint "The leader in human-centric cybersecurity" Website	vs.	Cisco Secure Email Defense "Advanced protection to safeguard your inboxes" Website
See Proofpoint plans (requires you to talk to a sales team) (according to a Reddit thread it may cost upwards of +$1000-2000 per month)	Pricing	Requires you to talk to a sales team
Unknown	Storage	Unknown
150 MB	Attachments	100 MB
No	Open-Source	No
No	Sandboxed Encryption	No
No	Unlimited Domains	No
No	Unlimited Aliases	No
No	TTI	No
❌ Requires 3rd party	SMTP	❌ Requires 3rd party
❌ Requires 3rd party	IMAP	❌ Requires 3rd party
❌ Requires 3rd party	POP3	❌ Requires 3rd party
Yes	API	Yes
No	E2EE	No
No	OpenPGP	No
No	WKD	No