Proofpoint vs Cisco Secure Email Defense Comparison (2025)

What are the differences between Proofpoint and Cisco Secure Email Defense?

Forward Email Team
Written by
Forward Email TeamVerified
Published
7/1/25
Time to read
Less than 5 minutes
We recommend Forward Email as the best alternative to Proofpoint.

Email Service Comparison

20 facts in comparison
Proofpointvs.Cisco Secure Email Defense

Proofpoint

The leader in human-centric cybersecurity
"The leader in human-centric cybersecurity"
  • Hardenize Test
  • Internet.nl Site Test
  • Internet.nl Mail Test
  • Mozilla HTTP Observatory Grade
  • Qualys SSL Labs SSL Server Test
vs.

Cisco Secure Email Defense

Advanced protection to safeguard your inboxes
"Advanced protection to safeguard your inboxes"
  • Hardenize Test
  • Internet.nl Site Test
  • Internet.nl Mail Test
  • Mozilla HTTP Observatory Grade
  • Qualys SSL Labs SSL Server Test
See Proofpoint plans (requires you to talk to a sales team) (according to a Reddit thread it may cost upwards of +$1000-2000 per month)PricingRequires you to talk to a sales team
UnknownStorageUnknown
150 MBAttachments100 MB
NoOpen-SourceNo
NoSandboxed Encryption No
NoUnlimited DomainsNo
NoUnlimited AliasesNo
NoTTI No
❌ Requires 3rd partySMTP❌ Requires 3rd party
❌ Requires 3rd partyIMAP❌ Requires 3rd party
❌ Requires 3rd partyPOP3❌ Requires 3rd party
YesAPIYes
NoE2EE No
NoOpenPGP No
NoWKD No

Email Service Screenshots

Closed-source

Proofpoint

Proofpoint is a closed-source email service. Its description from its website is: The leader in human-centric cybersecurity

Proofpoint is a closed-source email service.
Photo by Forward Email
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Closed-source

Cisco Secure Email Defense

Cisco Secure Email Defense is a closed-source email service. Its description from its website is: Advanced protection to safeguard your inboxes

Cisco Secure Email Defense is a closed-source email service.
Photograph by Forward Email
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Compare Proofpoint with 78 email services